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Conolidine’s analgesic outcomes stem from its interaction with non-opioid pain pathways. Unlike opioids, which bind to µ-opioid receptors within the central anxious procedure, conolidine modulates alternate molecular targets. A Science Advances review observed that conolidine interacts While using the atypical chemokine receptor ACKR3/CXCR7, whi… Read More


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These contain reduction in non-professional medical opioid use, mortality and morbidity (which includes because of opioid overdose, HIV and viral hepatitis), lowering danger of criminal offense and incarceration, far better retention in remedy, quality of life and All round wellbeing. Inside the rules on Group management of opioid overdose, WHO end… Read More